Pramipexole and yohimbine
Below a comment from a good friend (whom I have never met personally):
“I obtained a supply of pramipexole (Mirapex). This is one of the recent non-ergot dopaminergic drugs, used mainly for Parkinson’s. I find that it has a modest pro-sexual effect, in that it increases the intensity or erotic sensations somewhat. However, what is most impressive is its synergistic effect with yohimbine. The two together can produce remarkably powerful sensations. I have read that some of yohimbine’s effects are attributed to dopamine, even though it is most well-know for its effects on A2 [alpha-2-adrenergic receptors]. Thus the synergy is probably due to an interaction in the dopamine system.
“I take 0.25mg of pramipexole, along with 2.7-5.4 mg of yohimbine. The pramipexole side effects have been mild. There was slight nausea the first couple of times, but now I don’t experience the nausea. I still find yohimbine’s side effects unpleasant, but I can use less of it in combination with pramipexole.”